Cryogel-based cancer vaccines generate effective T cell and antibody responses independent of injection location, relative to the draining lymph node or tumor.
Ultrasound-triggered vaccine drug delivery
Shih, T-Y., Najibi, A.J., et al. Biomaterials 2021.
We leveraged noninvasive ultrasound to remotely trigger release of an adjuvant from cancer vaccines.
Chemo-immunotherapy in situ
Wang, H.*, Najibi, A.J.*, et al. Nature Communications 2020.
We used a hydrogel to both deliver chemotherapy, generating cancer antigen in situ, and concentrate activated dendritic cells to mobilize antitumor immunity, forming an effective "antigen-free" vaccine.
Engineering lymph nodes for cancer immunotherapy
Najibi, A.J. & Mooney, D.J. Advanced Drug Delivery Reviews 2020.
We review cell and tissue engineering strategies involving lymph nodes to advance cancer immunotherapy.
A cryogel vaccine against acute myeloid leukemia
Shah, N.J.*, Najibi, A.J.*, et al. Nature Biomedical Engineering 2020.
We developed a cryogel-based vaccine which provides prophylactic immunity against acute myeloid leukemia and, in combination with chemotherapy, eradicates established disease.
Recruited T cells rescue ischemic tissue.
Kwee, B.J., Seo, BR., Najibi, A.J., et al. Science Advances 2019.
A biomaterial scaffold implanted into an ischemic limb recruited antigen-specific Th2-type CD4+ T cells generated by a prior vaccine, supporting angiogenesis and muscle regeneration.